August 19, 2008
influenza antibodies
Survivors of the 1918 flu pandemic still carry the antibodies to combat the virus.
Their immune systems still carry a memory of that virus and can produce proteins called antibodies that kill the 1918 flu strain with surprising efficiency, the researchers report in the journal Nature.
“It was very surprising that these subjects would still have cells floating in their blood so long afterward,” said Dr. James Crowe of Vanderbilt University in Tennessee, who helped lead the study.
The antibodies also protected mice from the 1918 virus, which swept around the world at the end of World War One killing between 50 million and 100 million people, Crowe’s team reports in the journal Nature.
“The antibodies that we isolated are remarkable antibodies. They grab onto the virus very tightly and they virtually never fall off,” Crowe said in a telephone interview.
“That allows them to kill the 1918 virus with extreme potency, meaning it takes a very small amount of antibody.”
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